Biocatalysis
The production of many fine chemicals places high demands on enantiomeric purity. Therefore, biocatalysts with high regio- and enantioselectivity are particularly suitable for synthesis. To convert natural and non-natural, often poorly water-soluble and frequently toxic substances, specific whole-cell biocatalysts were designed, characterized by reaction engineering analyses, and many biotransformations were transferred to an industrial scale.
Finished research projects
- Production of D-xylitol from sugar beet press pulp with Aspergillus niger
- Reaction engineering analysis of D-galacturonic acid reduction to L-galactonate with recombinant Saccharomyces cerevisiae
- One-pot multi-enzyme syntheses: New strategies beyond whole cells and isolated enzymes
- Design of cosubstrate binding behavior of ene reductases for asymmetric syntheses
- Biphasic whole-cell production of geranyl glucoside by recombinant Escherichia coli
- Whole-cell biocatalysis with recombinant Gluconobacter oxydans strains
- Membrane functionalization of nano-scale enzyme membrane reactors for asymmetric syntheses
- Surface functionalization of nano-scale membrane reactors for multienzyme syntheses
- Scalable process for the production of nano-compartments made of ABA-triblock copolymers
- One-step expression and enzyme immobilisation in cellular envelopes of Escherichia coli
- Stereoselective multi-step reduction of dehydrocholic acid with hydroxysteroid dehydrogenases
- Asymmetric reductions using novel ene-reductases from cyanobacteria
- Biocatalytic production of cholic acid derivatives with hydroxysteroid dehydrogenases
- Biphasic whole-cell synthesis of R-2-octanol with recycling of the ionic liquid
- Asymmetric syntheses with new oxidoreductases from cyanobacteria
- Whole-cell biocatalysis in ionic liquids with recombinant Escherichia coli
- Supply of coenzymes in Saccharomyces cerevisiae for whole-cell biocatalysis
- Asymmetric syntheses with phototrophic microorganisms
- Whole-cell biocatalysis in the presence of ionic liquids
- Reaction engineering analysis of the asymmetric synthesis of chiral alcohols with Lactobacillus kefir
- Reaction engineering analysis of the asymmetric reduction of ß-ketoesters with recombinant yeasts