In many cases, downstream processing is by far the most cost-intensive step of a bioprocess. Often, multiple-step bioseparations are required yielding rather low product yields.
Therefore, existing bioseparation processes should be improved and combined to reduce the number of process steps. The focus is on bioprocess integration of fermentation/biocatalysis and downstream processing (and follow-up chemistry).
Finished research projects
- A Crystallographic and Molecular Dynamics Simulation Study of Protein Crystallization
- Crystal contact engineering to enhance protein crystallization processes
- Vibration packing of liquid chromatography columns
- Modeling of the transient hydrodynamic behavior of preparative chromatography columns
- Purification and formulation of a therapeutic antibody by crystallization
- Protein crystallization in stirred-tank reactors
- Optimization and modelling of protein refolding conditions
- Process integration of fermentation and catalysis for the production of succinic acid derivatives
- Integrated reactive extraction for recovery of biotechnologically produced succinic acid
- Disinfection of water with hydrodynamic cavitation and chlorine dioxide