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Technical University of Munich
Technical University of Munich

Modeling of the transient hydrodynamic behavior of preparative chromatography columns

Martin Dorn, doctoral thesis Technical University of Munich, 2017

The complex hydrodynamic packed bed behavior of preparative chromatography columns was described by a deterministic simulation model combining computational fluid dynamics (CFD) with the discrete element method (DEM). Using this modeling approach, the causes leading to the hysteretic packing behavior during cyclic operation were investigated for the first time and the influencing factors being experimentally inaccessible were uncovered. Thereupon, the hydrodynamic packing behavior was improved.

Publications

  • Dorn M, Eschbach F, Hekmat D, Weuster-Botz D (2017): Influence of different packing methods on the hydrodynamic stability of chromatography columns. J Chromatogr A 1516: 89−101.
  • Dorn M, Schilde C, Burmeister CF, Hekmat D (2017): Mechanical characterization of compressible chromatographic particles. Powder Technol 320: 213−222.
  • Dorn M, Hekmat D (2016): Simulation of the dynamic packing behavior of preparative chromatography columns via discrete particle modeling. Biotechnol Prog 32: 363-371.
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