The Professorship of Systems Biotechnology investigates both theoretical and experimental aspects of biotechnological processes. To this aid, methods and techniques of systems biology are specifically applied for analysis- and optimization tasks in a biotechnological context. These methods can be applied regardless of the chosen host organism.

Mathematical models describing cellular process are the foundation for optimization of the organism/process. In these models, not only different aspects of metabolism should be considered, but also the signal transduction, which plays an important role when organism are subject to changing environmental/fermentation conditions. In order to study the behaviour of cells under production conditions, the cellular models should eventually be coupled with reactor models. Experimental techniques are applied to describe bacterial physiology and to validate the mathematical models.

The goal of systems biotechnology is to optimize the entire biotechnological process. As a consequence, a range of optimization tasks arise, that concern process operation as well as the biological system. To acquire high-performance systems the metabolism and signal transduction of the organism need to be altered. This is where the field of synthetic biology comes into play, where tailored modules with specific functionalities are constructed. As an example, specific metabolic pathways can be removed or redirected.

Current research projects:

Former research projects: