Synthetic co-cultivation of C. carboxidivorans with C. kluyveri for syngas conversion

Miriam Bäumler, doctoral thesis Technical University of Munich, 2024

The establishment of a synthetic co-culture of Clostridium carboxidivorans and Clostridium kluyveri allowed the autotrophic conversion of carbon monoxide to longer-chain alcohols. 1-Butanol and 1-hexanol concentrations could be increased several fold compared to a pure culture of C. carboxidivorans. Transfer of the process to a continuously operated stirred-tank bioreactor cascade significantly increased the space-time yields for ethanol (factor 5.3), 1-butanol (factor 2.7), and 1-hexanol (factor 1.9).


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