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Technical University of Munich

Integration platform for workflow automation and digitalization in bioprocess laboratories

(M.Sc. Lukas Bromig)

Rapid integration of lab devices is enabled by a modular integration platform for workflow automation and digitalization. Drawing on industry standards, it presents a flexible, software architecture across a diverse range of instruments. Demonstrated on use cases, such as dynamic parallel bioreactor control based on real-time prioritization or adaptive evolution experiments, the platform accelerates research by improving interoperability, efficiency, and enabling data-driven experimentation.

Publications
  • Bromig L, Weuster-Botz D (2023): Accelerated adaptive laboratory evolution by automated repeated batch processes in parallelized bioreactors. Microorganisms 11: 275.
  • Bromig L, von den Eichen N, Weuster-Botz D (2022): Control of parallized bioreactors I: dynamic scheduling software for efficient bioprocess management in high-throughput systems, Bioproc Biosys Eng 45: 1927-1937.
  • Von den Eichen N, Osthege M, Dölle M, Bromig L, Wiechert W, Oldiges M, Weuster-Botz D (2022): Control of parallized bioreactors II: probabilistic quantification of carboyxlic acid reductase activity for bioprocess optimization, Bioproc Biosys Eng 45: 1939-1954.
  • Bromig L, Leiter D, Mardale A-V, von den Eichen N, Bieringer E, Weuster-Botz D (2022): The SiLA 2 manager for rapid device integration and workflow automation. SoftwareX 17: 100991.
  • Von den Eichen N, Bromig L, Sidarava V, Marienberg H, Weuster-Botz D (2021): Automated multi-scale cascade of parallel stirred-tank bioreactors for fast protein expression studies. J Biotechnol 332: 103-113.
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