Bioprocess Integration
The separation and purification of bioproducts from the aqueous product solution represents a significant cost factor in many bioprocesses. In biotechnology, downstream processing usually requires many different steps, leading to low overall yields. New separation and purification technologies were studied to reduce the number of process steps, with particular attention paid to process integration from fermentation/biocatalysis and product isolation to subsequent chemistry.
Finished research projects
- Crystal contact engineering of diverse enzymes to improve technical protein crystallization processes
- A Crystallographic and Molecular Dynamics Simulation Study of Protein Crystallization
- Crystal contact engineering to enhance protein crystallization processes
- Vibration packing of liquid chromatography columns
- Modeling of the transient hydrodynamic behavior of preparative chromatography columns
- Purification and formulation of a therapeutic antibody by crystallization
- Protein crystallization in stirred-tank reactors
- Optimization and modelling of protein refolding conditions
- Process integration of fermentation and catalysis for the production of succinic acid derivatives
- Integrated reactive extraction for recovery of biotechnologically produced succinic acid
- Disinfection of water with hydrodynamic cavitation and chlorine dioxide